Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators.

Selective androgen receptor modulators in preclinical and clinical development

Androgen receptor (AR) plays a critical role in the function of several organs including primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable therapeutic target. Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produc...

Nonsteroidal selective androgen receptors modulators (SARMs): designer androgens with flexible structures provide clinical promise.

Androgens play an essential role in differentiation and growth of the male reproductive tract, pubertal maturation and development of secondary male sex characteristics, initiation and regulation of spermatogenesis, and male sexual behavior (1). Steroidal androgens increase muscle mass, bone mass, and strength; stimulate male pattern baldness; and alter serum lipid profiles and fat distribution...

Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies

Purpose of review—The last decade has witnessed unprecedented discovery effort to develop selective androgen receptor modulators (SARMs) that improve physical function and bone health without adversely affecting the prostate and cardiovascular outcomes. This review describes the historical evolution, the rationale for SARM development, and the mechanisms of testosterone action and SARM selectiv...

Selective Androgen Receptor Modulators (SARMs): Muscle Growth Without Side Effects?,Former Steroid Users Have Low Testosterone,Anabolic steroids increase exercise tolerance,Effects of Androgenic-Anabolic Steroids in Athletes

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.